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About 1 in 8 couples in the United States experiences infertility. This number might seem high, but considering how many things need to go perfectly suitable to conceive, it’s not surprising.

There are many reasons why an individual or couple might have a hard time becoming pregnant, including factors related to ovarian health and egg quality, sperm quality (concentration, motility, shape), uterine health, and more.

For those having trouble conceiving, there are various options to seek or utilize that can help you get pregnant, some of which you can even begin to pursue on your own, like making changes to your diet and lifestyle to optimize your body for pregnancy. You can also work with your current OB/GYN or Primary Care Physician (PCP) to start with preliminary testing, such as basic ovarian reserve testing and a referral for a semen analysis.

For many looking into fertility treatments, two options become top choices to consider pursuing: intrauterine insemination (or IUI) and in vitro fertilization (or IVF).

For people struggling to conceive, an initial evaluation with a fertility specialist can help identify the root cause of infertility and factors that may be creating challenges. Reproductive Endocrinologists have extensive training and experience in evaluating problems that can interfere with conception — such as egg, sperm, uterine, or implantation issues — and are therefore best able to guide patients in choosing which treatments are best for them.

IUIs should be performed by a medical professional trained to do them. In most cases, IUIs are used in conjunction with medicated (oral pills) treatment cycles. IVF is a more involved treatment and should only be managed by an experienced reproductive endocrinologist (REI).

Below we’ll look at what IUI and IVF entail, the pros and cons of both treatments, and knowing which one is the right option for you.

What Is IUI?

IUI stands for intrauterine insemination. It involves having sperm injected into the uterus around the time of ovulation. This is done to bypass any potential cervical issues and decrease the sperm’s travel time to the egg and increase the likelihood of fertilization happening.

For whom is IUI a good option? It’s typically one of the first fertility treatments recommended for patients who have not gotten pregnant on their own within about six months to one year of trying depending on age. It’s a great option for those dealing with hormonal and fertility issues such as:

• Anovulation (lack of ovulation without help from medication)
• PCOS
• Cervical mucus problems
• Sperm quality issues
• It can also help same-sex couples using donor sperm, single mothers using donor sperm, and sometimes couples with unexplained infertility.

You might also hear IUI referred to as artificial insemination. IUI involves the sperm first being “washed” to increase its potency, then being delivered directly to the uterus.

“Washing” sperm means that a sperm sample is first collected, and then the sperm are separated to sort healthy, motile (swimming) sperm from the less healthy sperm and seminal fluid. Only the best quality sperm is used during an IUI; this way, there’s the greatest chance of the sperm being able to reach and penetrate the egg.

It’s essential that the individual is ovulating or just about to ovulate when IUI is performed because this is the only time that a person can get pregnant. Ovulation is when a mature egg is released from an ovary to begin its journey down the fallopian tubes, at which point it can be fertilized.

Before an IUI is performed, a doctor monitors the individual to track the timing of their cycle and ensure they are ovulating. Monitoring can be done using an ultrasound, which looks at egg follicles within ovaries, and sometimes with bloodwork.

Here are the basic steps involved in an IUI cycle:

• The IUI cycle begins on the first day of a person’s period and the egg(s) mature inside the ovaries for about the next two weeks leading to ovulation.
• Some people will take medications to encourage ovulation during this period. For example, medications (such as oral meds like Clomid or Letrozole or injectable hormone medications called gonadotropins) can be used to stimulate more eggs to mature and be released.
• In most cases, the IUI will take place on the day of ovulation or sometimes the day prior. This is determined using monitoring. A “trigger shot” might also be used to time ovulation since this medication induces ovulation within about 36 hours.
• A sperm sample from either a partner or a donor will be provided to the doctor’s office, then washed.
• The doctor/practitioner will insert the washed sperm sample into the uterus using a thin catheter. This is primarily painless and only takes a couple of minutes.
• After the IUI, the person will lay down and relax for about 10 minutes, and then they are free to leave the doctor’s office and go about their day. Hopefully, at this point, fertilization takes place.

What are the advantages of IUI?

Below are some of the main advantages of IUI:

• Less invasive and less expensive compared to IVF. A typical IUI cycle can cost about $1000 (depending on your insurance), while IVF can cost $20,000 per cycle.

• IUI Deposits the best quality sperm possible close to where the egg is waiting, which increases the chances of becoming pregnant in comparison to conceiving through intercourse.
• Uses monitoring to ensure that insemination happens at the time of ovulation.
• IUI cycles can either use medications or not, depending on the specific situation. Those who have difficulties ovulating, such as those with irregular periods or PCOS, can use medications to help release more mature eggs.
• Not using ovulation medication can help lower the cost. This is a good approach for those who ovulate regularly or who are using donor sperm.

Who performs IUIs?

IUIs cannot be performed at home without proper processing and washing of seminal fluid; however, some people may try intravaginal or intracervical inseminations at home, with significantly less success. Most often, people choose to see a medical professional for the procedure. OB/GYNs can perform IUI, which means patients may be able to work with their previous provider if they prefer (only reproductive endocrinologists can perform IVF, however).

That being said, patients often choose to work with a fertility specialist or an REI for an IUI because an REI can perform thorough tests prior to an IUI in order to gain more advanced knowledge of a patient’s fertility status and obstacles.

Specialists typically have cutting-edge technology and equipment and are capable of uncovering a great deal of information about the quality of one’s sperm, eggs, anatomy, menstrual patterns, and so on, which can help increase success with IUI.

How successful is IUI?

IUI is said to have “modest results” in terms of success, meaning it isn’t guaranteed to work and isn’t necessarily more successful than two healthy people having intercourse.

In best-case scenarios, it’s successful about 7% to 20% of the time per IUI cycle, depending on the woman’s age. If a couple tries IUI several times and does not have severe damage to fallopian tubes and has decent quality sperm, they may have a 50% chance of getting pregnant with up to six rounds of IUI.

Overall, success rates depend on the couple’s age, the timing of the procedure, and the health of the eggs and sperm. Individuals younger than 35 tend to have more success with IUI than those over 35 to 40 years old.

Are there any side effects of IUI?

IUI typically doesn’t hurt, although it may feel a bit uncomfortable. Some people experience mild cramping during the procedure. Afterward, it’s okay for the person to resume normal activities, as they’re unlikely to feel any significant side effects.

Side effects can be more noticeable if medications are being taken. For example, ovulation medications can sometimes cause temporary bloating, cramping, water retention, and breast pain.

There’s also a higher likelihood of having multiples (twins or triplets) if using gonadotropin medications with IUI since these drugs can cause multiple eggs to be released and potentially fertilized.

What Is IVF?

IVF stands for in vitro fertilization. It’s a fertility treatment that fertilizes eggs with sperm in a lab (“in vitro” refers to a process performed in a laboratory culture dish instead of inside the body).

IVF is one type of artificial reproductive technology (or ART). IVF aims to stimulate the ovaries to mature as many healthy eggs as possible in a given cycle in order to create embryos. In the majority of cases patients pursuing IVF choose to utilize genetic testing, which entails a few cells being removed from the embryos for testing prior to freezing. Through genetic testing, your REI physician will be able to dramatically increase the likelihood that the embryo being transferred into the uterus is genetically healthy and increase the liklihood of getting pregnant. There are many reasons individuals or couples choose to pursue IVF when growing their family, including various causes of infertility, wanting to utilize genetic testing on embryos, or moving on from other fertility treatments that have been unsuccessful.

The entire IVF process can usually occur within three months. Medications are first used to help eggs inside the ovaries mature, then as many eggs as possible are removed from the body with help from an egg retrieval procedure. The mature eggs are then mixed with a sperm sample in a lab (called insemination), hopefully facilitating fertilization and embryo formation. In frozen embryo cycles, embryos are then frozen to allow for the woman’s body to return to normal after stimulation within a few weeks. The final step is the frozen embryo transfer which occurs after the uterus is primed with estrogen and progesterone for approximately three weeks. In this minor painless procedure, an embryo is released inside the uterus with the aid of ultrasound guidance.

To summarize the steps above, a cycle of IVF includes several steps:

• Ovarian stimulation using injectable medications.
• Egg retrieval from the ovaries.
• Fertilization of retrieved eggs using a semen sample within a laboratory.​​
• Optional but recommended preimplantation genetic testing of embryos prior to freezing them.
• Uterine lining preparation.
• Transfer of the fertilized embryo back into the uterus using a thin tube through the cervix under ultrasound guidance
• Then hopefully, pregnancy occurs!

There are several additional treatment options available with IVF, including using intracytoplasmic sperm injection (or ICSI), Preimplantation Genetic Testing (PGT), or using donor eggs, donor sperm, or a gestational carrier (surrogate). Including any of these options into your treatment plan will all depend on the couple’s specific needs.

Who is IVF best suited for? Depending on the factors contributing to infertility, IVF may be the best choice and recommended as the primary treatment plan due to its significantly higher success rates than IUI. However, less aggressive initial attempts with IUI cycles would also be appropriate in many situations due to its less invasive and costly nature. In general, IVF would be a good first choice for those with the following conditions:

• Damaged, blocked, or absent fallopian tubes (the procedure bypasses the fallopian tubes, where ovulation typically takes place).
• Poor sperm quality (it can be successful even with very little healthy sperm, as explained more below).
• Prolonged unexplained infertility.
• Problems with ovulation that are not being solved with other treatments.
• Severe endometriosis
• A genetic disorder that can be passed down to offspring.

IVF With ICSI:

ICSI is a procedure only available during IVF and cannot be performed with an IUI. It involves having a single healthy sperm be injected into a mature, retrieved egg. Research shows ICSI typically fertilizes between 50% to 80% of eggs. ICSI is often recommended as a good option when undergoing IVF treatment if:

• The partner produces too few sperm to do IUI or traditional IVF (in which 50,000 sperm are used to inseminate a retrieved egg).
• Sperm aren’t motile, or sperm have trouble attaching to or penetrating the thick outer layer of the egg.
• There’s a blockage in the reproductive tract that is preventing sperm from exiting.
• Traditional IVF fertilization has not worked for unknown reasons.
• Eggs that were previously frozen are being used.

What are the advantages of IVF?

Below are some of the main advantages of IVF:

• Considered the most potent fertility treatment, it can help couples get pregnant when other options cannot.
• It can help address reproductive issues related to both egg and sperm providers, including egg and sperm health and problems with the cervix and fallopian tubes.
• It can help treat age-related infertility and prolonged unexplained infertility, which often lead to unsuccessful treatment with  IUI.
• It offers the option of using ICSI, which IUI does not.
• It offers the option of using genetic testing, which IUI does not. This reduces concerns regarding certain genetic disorders since embryos can be tested before being implanted to identify genetic disorders or chromosomal abnormalities.
• It offers the option of storing embryos to be used and transferred at another time.

Preimplantation Genetic Testing:

One of the significant advantages of IVF is that it allows for genetic testing of embryos, including for inherited familial diseases, which IUI and other fertility options do not.

Called Preimplantation Genetic Testing (or PGT), this type of testing is performed to identify if embryos have a specific genetic or chromosomal condition. This way, those embryos are not transferred to the uterus, and the defect is not passed onto the offspring. The goal is to ensure that healthy embryos are transferred to the uterus in order to sustain a pregnancy and result in a healthy baby.

PGT also helps address the fact that one of the most common reasons embryos do not transfer and result in pregnancies is because of abnormal embryo genetic factors.

PGT may be recommended for couples or patients with a history of single-gene disorders, such as cystic fibrosis or sickle cell anemia, or sex-linked disorders, such as Duchenne muscular dystrophy and Fragile X syndrome.

How successful is IVF?

IVF now accounts for up to 4.5% of all live births in the United States and Europe.

The chances of getting pregnant with help from IVF ultimately depend on a number of factors, including age and overall health status, the underlying reason for infertility, and how many healthy embryos were created.

Like with IUI, IVF is most successful when the person providing eggs is younger than 35 to 40 years old and generally healthy. Overall, women between 30 and 40 have about a 40% to 50% chance of IVF working depending on several factors, and however, with the advent of PGT testing, a genetically normal embryo would have an approximately 70% chance of resulting in a healthy pregnancy in a high-quality fertility clinic.

Are there any side effects?

IVF involves using medications that can cause side effects, such as bloating, nausea, water retention, headaches, and mood swings. These are temporary and usually last about one week or so.

The egg retrieval procedure is performed under anesthesia and takes approximately 15-20 minutes. After the process, there may be some mild discomfort, including cramping, swollen ovaries, light bleeding, and tenderness. Following IVF, patients should avoid anything too strenuous, or that involves twisting of the ovaries.

Depending on the medications used in the IVF stimulation, there may also exist a minimal risk of ovarian hyperstimulation, which is a condition that can cause the ovaries to become temporarily swollen and painful, and in very rare circumstances, requires fluid to be removed from the abdomen.

IUI Vs. IVF: Which Is Right For You?

There’s a lot to consider when deciding between IUI and IVF, including the cost, invasiveness, time commitment, use of medications, potential side effects, and success rates.

An IVF cycle is more involved, invasive, and expensive than an IUI cycle; however, it can also be significantly more successful when IUI and medications are not.

If you’re dealing with infertility, your provider will help guide you through the process.

Your fertility provider will run tests to determine things like your egg and sperm quality and then be able to advise you on options that are most likely to be successful. Because every infertility situation is unique and complex, it’s best to listen to your provider’s recommendations regarding your treatment plan.

Is it worth trying IUI before IVF?

You and your doctor together can review your current health status and the specific conditions you’re facing to determine if IUI should be performed first or if it is in your best interest to move directly to IVF as your first-line treatment choice.

In many cases, if appropriate, your physician may recommend trying up to three cycles (sometimes up to six) of medicated IUI before moving onto IVF, assuming there are no significant obstacles that can interfere with IUI being successful. Sometimes certain insurance companies will require this before paying for IVF.

Some doctors may suggest that women in their 40s only try IUI once or twice before going to IVF, or even that they go straight to IVF to not waste time.

How do you know if you should do IUI first or go straight to IVF?

According to fertility experts, here is when to consider IUI before moving on to IVF:

• Try IUI first if your infertility is mainly related to ovulation issues. This includes individuals with PCOS or other forms of anovulation, plus cervical mucus problems.
• If the partner providing sperm has moderate sperm health issues but is still producing healthy amounts of sperm, try IUI first.
• Same-sex couples and single parents trying to conceive with donor sperm can also try IUI first.
• If the egg provider is under 35 or between 35 and 40 with no significant known fertility issues, IUI is typically done before IVF.

IVF may be a better option if 3-6 IUI cycles have been unsuccessful, or if the individual providing eggs or carrying the pregnancy is in their 40s, there is very little good quality sperm, or if there are known problems with uterine or fallopian tube function.

Family planning is another crucial element to consider when deciding where to start. If more than one child is desired, and advanced female age is one of the issues, IVF may be the best option in order to provide ample opportunity for fertility preservation through embryo creation. This future planning can allow individuals and couples to build the family of their dreams instead of enduring a long fertility journey that results in a significant decrease in the chance of additional successful cycles and future children.

Don’t forget to discuss these issues with your trusted REI so they can guide you appropriately.

Deciding to start a family can be one of the most exciting life decisions a person can make. However, if a couple or individual has difficulty conceiving, joy and excitement can turn into stress and despair.

Unfortunately, infertility is not uncommon. This global issue affects about 48 million couples and 186 million individuals worldwide. So even if you’re not personally struggling with infertility, chances are likely that you know someone who is.

Infertility takes a mental, physical, and emotional toll on those longing to become parents. So how can you best support a friend who’s going through infertility?

What is Infertility?

Infertility is being unable to get pregnant after a year or more (6 months if over the age of 35).

Infertility affects all genders and can be due to several causes. Issues with any of the many steps that lead to conception can cause infertility.

For many people, infertility can occur when there are problems with their reproductive organs — such as the fallopian tubes, uterus, ovaries, testicles, or sperm. Smoking, obesity, alcohol or drug use, radiation exposure, genetic factors, and some medications increase the risk of infertility.

Infertility impacts everyone differently, and people may cope in various ways. It can be heartbreaking when someone wants to become a parent and is met with challenges.

You may be unsure what to do or say if your friend or family member is dealing with infertility. Still, there are several ways to support them.

Talking to Those Struggling With Infertility

When talking to a loved one with infertility, the most important thing is to let them know you’re there for them. Just asking how you can help goes a long way. Infertility comes with many complex emotions, so let your friend know they can talk to you if they feel like discussing it.

What Not to Say to a Friend with Infertility

What NOT to say is just as important as what you say. You may be trying to frame things in a positive light. For instance, saying things like “at least you don’t have cancer” or “at least you have freedom since you don’t have kids” is not helpful. But instead, statements like these minimize the pain of infertility. Just because infertility isn’t life-threatening doesn’t mean it’s not devastating to those trying to conceive.

Don’t Give Advice

Also, avoid advising on what they should do, like telling them to adopt. Adoption is a different journey that comes with its complexities. Your friend may not be ready to think about adoption just yet. On top of that, adoption can be a significant financial strain.

Fertility treatments can also be costly as well as mentally and physically taxing. So it’s best not to push your friend to pursue fertility treatments or tell them what to do about their infertility. In addition, you may not know everything they’ve tried or what it’s like to undergo fertility treatments.

Communicate Openly and Mindfully

Open communication is vital; you shouldn’t hide your pregnancy just because your friend is struggling with infertility. They’re probably very happy for you! But it’s a good idea to drop the news to them in private, so they have time to process it on their own time. You could even give them an individual heads up before posting about your pregnancy on social media.

Supporting a Friend With Infertility

Besides mindful and empathetic communication, there are more concrete ways to support someone struggling with infertility.

Learn About Infertility

Everyone in your friend’s circle may be curious about their infertility and ask them lots of questions about it. Yet, it can be exhausting to constantly rehash all the same information to different people.

You can take some of the burdens off your friend by researching and learning about infertility. Educate yourself about infertility and fertility treatments, like in vitro fertilization or intracytoplasmic sperm injection, so you’ll be on the same page if your friend ever wants to discuss it.

Offer to Help out with Tasks.

Infertility and fertility treatments are mentally and physically exhausting. You can support your friend by helping out with mundane tasks like housework or dropping off a meal. You could offer to attend fertility appointments with your friend or watch their pets so they can have time for self-care.

Ask How They’re Doing and if They Need Anything

The best way to support your friend on the journey to becoming a parent is to ask what they need. For example, some people want a listening ear to talk about it, while others require a mental break.

Remember to check in with your friend and say, “I’m here if you want to talk about it. What do you need from me?”

Don’t Be Afraid to Talk About It

While you want to avoid giving advice, don’t be afraid to talk about infertility. This is where you should let your friend take the lead. They may or may not want to discuss it, but it’s a profound part of their life.

Those struggling with infertility may feel isolated. Many of their friends and family are throwing baby showers and starting families while they fight a silent battle to become a parent. Let your friend know you’re here if they want to talk, and respect their medical decisions surrounding infertility. Don’t try to convince them to do something you may think they should do, and also respect their decision to stop treatments.

Hold Space to Help Your Friend Get Through Their Infertility Struggles

Infertility affects everyone differently, and it’s never an easy journey. The most important thing you can do is lead with love and hold space for whatever your friend is going through. Be a haven for them to laugh, cry, and everything in between. If you communicate with empathy, love, and honesty, you can provide the support your friend needs most.

If you or anyone you know is dealing with infertility, you don’t have to do it alone. At Reproductive Gynecology and Fertility, we provide comprehensive fertility care so those struggling with infertility can successfully become parents. Visit us at Reproductive Gynecology & Infertility to learn more about how we can help.

Endometriosis is when endometrial tissue develops outside the uterus, causing inflammation, discomfort, and infertility.

Stages of Endometriosis:

Stage 1 — Minimal

A few superficial lesions, or implants, on the tissue of your pelvis or abdomen with little to no scar tissue.

Stage 2 – Mild

Implants are deeper with some scar tissue.

Stage 3— Moderate

Multiple deep lesions, small cysts on your ovaries, and thick bands of scar tissue.

Stage 4 — Severe

Widespread deep tissue implants, thick scar tissue, and larger cysts on both ovaries

Diagnosing Endometriosis:

Your healthcare provider may perform:

Ultrasound

Imaging of your internal organs using sound waves.

CT Scan

Imaging with computer technology and X-rays to see abnormalities in the body.

MRI

Two-dimensional imaging of your organs.

Laparoscopy

Performed by inserting a tiny tube with a camera into your abdomen to assess endometrial growth.

Endometriosis Treatment:

Pain relief

Over-the-counter pain medicine to relieve discomfort.

Hormone therapy

Hormones to decrease menstrual symptoms and ovulation.

Laparoscopy

A small scope is used to find and remove endometrial growths.

Hysterectomy

Removal of the uterus.

What does endometriosis have to do with infertility?

20-40% of women with infertility have endometriosis.

Endometriosis results in inflammation, affecting the function of your reproductive organs.

It causes scar tissue formation in the pelvic area and adhesion-related distortions of the fallopian tubes, interfering with egg fertilization and implantation.

Contact Reproductive Gynecology and Infertility (RGI) to learn more about endometriosis and infertility treatments.

Polycystic Ovarian Syndrome, commonly known as PCOS, is one of the leading causes of infertility. As many as five million women in the U.S. are affected by this condition, which may impact ovulation. The condition can make conceiving difficult, but treatments are available and are associated with high success rates. Women with PCOS who are interested in conceiving may respond to a combination of lifestyle changes and medical treatment, so it’s important to reach out to a specialist for evaluation. Today we’ll look at what PCOS is, how it affects fertility, and what you can do to increase your odds of getting pregnant if you have PCOS.

What is PCOS?

Polycystic Ovarian Syndrome is a hormonal problem that causes ovulation to be erratic, infrequent, or even entirely absent. Women who do not ovulate regularly will complain of irregular or absent menses.

The name of the condition tells us something about it. “Poly” = “many,” and “cystic” = “having to do with cysts.” PCOS is a condition where there are many small follicles that are arrested in development. Usually, one follicle will develop a mature egg each cycle. In PCOS, the ovarian environment is dominated by androgens like testosterone and insulin resistance. This impairs the development of the follicle and prevents an egg from maturing.

How Does PCOS Affect Fertility?

For conception to take place, your body must produce and release a mature egg. If you don’t ovulate, you cannot get pregnant. Most people ovulate monthly, and the less frequently you ovulate, the fewer opportunities there are to get pregnant. While exact numbers are difficult to pin down due to the variability of severity and symptoms in PCOS, the 2015 Australian Longitudinal Study on Women’s Health found that 72% of participants with PCOS reported fertility problems, compared to 16% in those who did not have PCOS.

Getting Pregnant with PCOS

If you have PCOS, the most important step toward getting pregnant is to induce ovulation. Since ovulation may be irregular in women with PCOS, it can be difficult to identify your fertility window. In women who do not have menses, there is no opportunity to conceive due to a lack of ovulation. Many women with PCOS are prescribed hormonal contraception to help improve their bleeding; therefore, they may be unsure of their cycle regularity once they stop taking hormonal medication. If normal menses does not occur one month after stopping the hormonal medication, this may indicate an ovulation disorder.

In addition, the weight gain often associated with PCOS can make ovulation even less likely. For women with an increased body mass index (BMI), lifestyle approaches such as dietary changes and exercise may result in ovulatory cycles.

Lifestyle Changes that Can Increase Your Chances of Pregnancy

If you have PCOS and you’re overweight, one of the simplest things you can do to increase your chances of getting pregnant is to lose weight. Losing only five to ten percent of your current weight is often enough to restart ovulation. If you’re not overweight, weight loss is unnecessary. However, other non-drug options may be beneficial regardless of your weight.

Here are a few lifestyle changes that could help:

Watch What You Eat

There is no one-size-fits-all option for women with PCOS who are trying to lose weight, but caloric restriction is generally ideal.

• Decreasing the intake of carbohydrates and foods with high glycemic load is beneficial for women with PCOS because many women with PCOS have insulin resistance.
• Avoid intake of sugary beverages like soda, and try to buy less packaged food.
• Include high-fiber foods and lean protein in your daily diet, and pass on red meat.

These dietary changes may help decrease the risk of developing diabetes, which is common among women with PCOS, and promote weight loss — both of which will help to restore ovulation and decrease the risk of complications in pregnancy.

Exercise regularly

For roughly half of those diagnosed with PCOS, exercise can help regularize menstrual cycles and improve ovulation. And, of course, exercise can support weight loss. This doesn’t mean you have to take out a gym membership or invest in expensive equipment; walking and yoga are easy, enjoyable ways to include exercise in your daily routine. There are other benefits of exercise as well, and women with PCOS who exercise regularly report a higher quality of life.

Medications That Can Assist Ovulation

Along with lifestyle modifications, several drugs can help PCOS patients restart or regularize ovulation and get pregnant.

Metformin

Metformin is commonly prescribed to help decrease the development of diabetes in women with PCOS but does induce ovulation. Metformin is commonly used in conjunction with letrozole to help induce ovulation in women with PCOS. It may be started in women with abnormal glucose testing or for women who failed to respond to letrozole or Clomid.

Letrozole and Clomid

These drugs are standard fertility drugs used to increase the regularity of ovulation and stimulate ovulation in people who do not ovulate. While both improve the likelihood of getting pregnant, letrozole appears to be more effective in achieving ovulation for women diagnosed with PCOS.

When to Seek Fertility Treatment

For patients with a diagnosis of PCOS, a pre-conception visit with either an OBGYN or a fertility specialist is important. Women should start incorporating lifestyle modifications (and start a prenatal vitamin) prior to conception.

For women who are not having regular periods, it’s important to seek help immediately so that a proper evaluation can be completed. Male partners should also be evaluated, as many couples have male and female problems.

If pregnancy is not achieved after three to six cycles, it may be time to consider other approaches to fertility treatment, such as IVF. Our fertility specialists can help you explore your options with your unique needs and goals.

Yes, You Can Get Pregnant with PCOS

While PCOS is one of the most common causes of infertility, it’s also one of the most treatable. If you’re ready to take the next step on your fertility journey, contact us today for a consultation.